444325-68-2Relevant academic research and scientific papers
Design, synthesis and evaluation of constrained tetrahydroimidazopyrimidine derivatives as antagonists of corticotropin-releasing factor type 1 receptor (CRF1R)
Vrudhula, Vivekananda M.,Dasgupta, Bireshwar,Pin, Sokhom S.,Burris, Kevin D.,Balanda, Lynn A.,Fung, Lawrence K.,Fiedler, Tracey,Browman, Kaitlin E.,Taber, Matthew T.,Zhang, Jie,Macor, John E.,Dubowchik, Gene M.
scheme or table, p. 1905 - 1909 (2010/07/04)
Several tetrahydroimidazopyrimidines were prepared using silver assisted cyclization as the key step. The binding affinities of compounds thus prepared were evaluated in vitro toward hCRF1R. Initial lead compound 16 (Ki = 32 nM) demo
