444325-99-9Relevant articles and documents
Synthesis and structure-activity relationship of imidazo[1,2-a] benzimidazoles as corticotropin-releasing factor 1 receptor antagonists
Han, Xiaojun,Pin, Sokhom S.,Burris, Kevin,Fung, Lawrence K.,Huang, Stella,Taber, Matthew T.,Zhang, Jie,Dubowchik, Gene M.
, p. 4029 - 4032 (2005)
8-Aryl-1,3a,8-triaza-cyclopenta[a]indenes represent a novel series of high binding affinity corticotropin-releasing factor 1 receptor antagonists. Here, we report their synthesis, SAR, and pharmacokinetic properties of compound 8e (Ki = 23 nM).