444326-41-4Relevant academic research and scientific papers
Discovery of 6-chloro-2-trifluoromethyl-7-aryl-7H-imidazo[1,2-a]imidazol-3- ylmethylamines, a novel class of corticotropin-releasing factor receptor type 1 (CRF1R) antagonists
Zuev, Dmitry,Vrudhula, Vivekananda M.,Michne, Jodi A.,Dasgupta, Bireshwar,Pin, Sokhom S.,Huang, Xiaohua Stella,Wu, Dedong,Gao, Qi,Zhang, Jie,Taber, Matthew T.,MacOr, John E.,Dubowchik, Gene M.
scheme or table, p. 3669 - 3674 (2010/09/04)
A novel series of [6-chloro-2-trifluoromethyl-7-aryl-7H-imidazo[1,2-a] imidazol-3-ylmethyl]-dialkylamines was discovered as potent CRF1R antagonists. The optimization of binding affinity in the series by the parallel reaction approach is discus
