4444-70-6Relevant academic research and scientific papers
DEMETHYLASE ENZYMES INHIBITORS
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Page/Page column 64, (2013/10/21)
A compound of formula (I) and its use as an inhibitor of one or more histone demethylase enzymes.
Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1
Zhang, Pengtao,Yang, Xinye,Zhang, Feiran,Gabelli, Sandra B.,Wang, Renxiao,Zhang, Yihua,Bhat, Shridhar,Chen, Xiaochun,Furlani, Manuel,Amzel, L. Mario,Liu, Jun O.,Ma, Dawei
, p. 2600 - 2617 (2013/06/27)
Cellular protein synthesis is initiated with methionine in eukaryotes with few exceptions. Methionine aminopeptidases (MetAPs) which catalyze the process of N-terminal methionine excision are essential for all organisms. In mammals, type 2 MetAP (MetAP2)
Diastereoselective functionalisation of benzoannulated bicyclic sultams: Application for the synthesis of cis-2,4-diarylpyrrolidines
Kelleher, Susan,Quesne, Pierre-Yves,Evans, Paul
supporting information; experimental part, (2010/04/22)
The cis-dibromination of unsaturated bicyclic bridgehead sultams 5a and 5b, and experiments designed to understand the cisstereochemical outcome of these reactions, are described. In the case of 5b, a novel solvent dependent carbocation rearrangement occu
Synthesis of enantioenriched 2-substituted 4-phenylbutylamines by hydrogenolysis of optically pure 6-alkoxy-5,6-dihydro-4H-1,2-oxazines
Buchholz, Monika,Hiller, Florian,Reissig, Hans-Ulrich
, p. 2838 - 2843 (2007/10/03)
Lewis acid promoted exchange of the 6-ethoxy group of 6H- 1,2-oxazines 1-3 with (-)-menthol furnished the optically active heterocycles 4-6. Diastereomers 4a and 4b, which could be separated efficiently by chromatography, were excellent substrates for hig
