444574-98-5Relevant academic research and scientific papers
1,2,3-Triazole-gold(I)-triethylposphine derivatives active against resistant Gram-positive pathogens
Contreras, Jean-Marie,Michaut, Mathieu,Morice, Christophe,Schalk, Isabelle J.,Steffen, Alexandre,Mislin, Ga?tan L. A.,Plésiat, Patrick
, (2021)
Innovative organogold(I) antibacterial compounds were synthesized by click chemistry with triethylphosphine-gold(I) azides and an alkyne derivative. The resulting organo-gold(I) compounds exhibit high levels of antibacterial activity against Gram-positive pathogens, with particularly low MICs against Clostridium difficile.
GOLD (I)-PHOSPHINE 1,2,3-TRIAZOLE DERIVATIVES WITH ANTIOBIOTIC PROPERTIES
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Page/Page column 103, (2020/01/11)
The present invention relates to gold (l)-phosphine 1,2,3-triazole compounds, and their use in a human or animal medicine. The present invention also relates to using such compounds for the prevention and/or treatment of an infection, i.e. inhibitors of growth of Gram-positive and/or Gram-negative bacteria. On another aspect the invention relates to the synthesis of the gold (l)-phosphine compounds of the invention and to their synthesis intermediates. The present invention finds applications in the medical, veterinary and/or chemical fields.
Propargyloxycarbonyl (Poc) amino acid chlorides as efficient coupling reagents for the synthesis of 100% diastereopure peptides and resin bound tetrathiomolybdate as an effective deblocking agent for the Poc group
Bhat, Ramakrishna G.,Sinha, Surajit,Chandrasekaran, Srinivasan
, p. 812 - 813 (2007/10/03)
Synthesis of short peptides using propargyloxycarbonyl amino acid chlorides as effective coupling reagents and polymer supported tetrathiomolybdate as an efficient deblocking agent are reported.
