444575-81-9Relevant academic research and scientific papers
A stereospecific ruthenium-catalyzed allylic alkylation
Trost, Barry M.,Fraisse, Pierre L.,Ball, Zachary T.
, p. 1059 - 1061 (2002)
Good regioselectivity and chirality transfer for aryl-substituted allyl units is achieved in allylic alkylations with a wide range of nucleophiles by using the highly active ruthenium catalyst 1. This method provides a route to antidepressants such as (-)-fluoxetine from (S)-ephedrine (see scheme; Cp* = η5-C5Me5, TBAT = tetrabutylammonium triphenyldifluorosilicate).
