444583-94-2Relevant academic research and scientific papers
Rhodium-catalyzed ortho-C-H olefination of aromatic aldehydes employing transient directing strategy
Liu, Xi,Wang, Zhonghao,Chen, Qun,He, Ming-Yang,Wang, Liang
, (2018)
A Rhodium(III)-catalyzed ortho-C-H olefination of aromatic aldehydes in the presence of catalytic amount of TsNH2 has been developed. The in situ generated imine intermediate from aldehyde and TsNH2 worked as a transient directing gr
Copper Catalyzed One-Pot Three-Component Imination-Alkynylation-aza-Michael Sequence: Enantio- And Diastereoselective Syntheses of 1,3-Disubstituted Isoindolines and Tetrahydroisoquinolines
Das, Braja Gopal,Shah, Sadhna,Singh, Vinod K.
supporting information, p. 4981 - 4985 (2019/07/08)
An enantio- and diastereoselective syntheses of 1, 3-disubstituted isoindolines and tetrahydroisoquinolines via CuI-Pybox-diPh catalyzed one-pot imination-alkynylation-aza-Michael sequence has been reported. The three-component reaction produces one C-C and two C-N bonds sequentially with high yield (up to 92%), enantioselectivity (up to 99%), and diastereoselectivity (up to 9:1) in a single operation. Furthermore, the synthetic utility of the product has been demonstrated by LiAlH4 reduction of ester and hydrogenation of alkyne functionality without losing the stereoselectivity.
Piperazine- and piperidine-derivatives as melanocortin receptor agonists
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Page/Page column 90, (2010/02/06)
The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction.
