444615-53-6

Upstream product

• 60736-71-2 3-methyl-4-methoxybenzyl chloride 
• 603-35-0 triphenylphosphine 

Downstream Products

• 922496-75-1 1-Bicyclo[2.2.1]hept-1-yl-2-(4-methoxy-3-methyl-phenyl)-ethane-1,2-dione 
• 444615-55-8 5-[(E)-2-(4-Methoxy-3-methylphenyl)ethenyl]-4-[(tetrahydro-2H-pyran-2-yloxy)methyl]-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole 

Relevant academic research and scientific papers

NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES

This invention relates to novel compounds having the structural formula (I) below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.

CYCLOALKYL AMINO-HYDANTOIN COMPOUNDS AND USE THEREOF FOR BETA-SECRETASE MODULATION

The present invention provides a 2-amino-5-cycloalkyl-hydantoin compound of formula I The present invention also provides methods and compositions for the inhibition of β-secretase (BACE) and the treatment of β-amyloid deposits and neurofibrillary tangles.

Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors

The present invention provides a compound of formula (1) wherein R1-R5, R25, R26, Y and X2 are defined as in claim 1. The compounds activate human peroxisome proliferator activated receptors (hPPARs) and arc useful for the treatment of associated disorders such as cardiovascular disease and hypercholesteremia.