444620-74-0 Usage
Chemical class
Piperazine derivatives
Use
Building block in the synthesis of bioactive compounds
Application
Key intermediate in pharmaceutical industry drug development
Structure
Unique
Benefits
Valuable tool for medicinal chemists
Potential applications
Treatment of neurological disorders and neuroscience research.
Check Digit Verification of cas no
The CAS Registry Mumber 444620-74-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,4,6,2 and 0 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 444620-74:
(8*4)+(7*4)+(6*4)+(5*6)+(4*2)+(3*0)+(2*7)+(1*4)=140
140 % 10 = 0
So 444620-74-0 is a valid CAS Registry Number.
InChI:InChI=1/C18H27N3O2/c1-18(2,3)23-17(22)21-12-10-20(11-13-21)15-8-4-6-14-7-5-9-19-16(14)15/h4,6,8,19H,5,7,9-13H2,1-3H3
444620-74-0Relevant articles and documents
Privileged structure-based ligands for melanocortin receptors - Tetrahydroquinolines, indoles, and aminotetralines
Fisher, Matthew J.,Backer, Ryan T.,Husain, Saba,Hsiung, Hansen M.,Mullaney, Jeffrey T.,O'Brian, Thomas P.,Ornstein, Paul L.,Rothhaar, Roger R.,Zgombick, John M.,Briner, Karin
, p. 4459 - 4462 (2007/10/03)
Substitution of the aryl sulfonamide moiety contained in MC4 agonist 1 with bicyclic heterocycles and aminotetralines produced compounds with MC4 activity. The heterocycles represent alternative privileged structures to that contained in 1. Compounds in which the polar group of the privileged structure was displayed in an endocyclic fashion were not as active as the parent agonist 1, while those with an exocyclic polar group afforded activity competitive with 1.
