444680-80-2

Upstream product

• 444680-78-8 2,2,2-Trichloro-N-[(1R,2S,5S,6R)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5,6-dihydroxy-4-methyl-1-vinyl-cyclohex-3-enyl]-acetamide 
• 444680-77-7 2,2,2-Trichloro-N-[(1R,2R,3R,4S,6S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-6-methyl-3-vinyl-7-oxa-bicyclo[4.1.0]hept-3-yl]-acetamide 
• 253674-42-9 2,2,2-Trichloro-N-[(1R,2S,6S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-4-methyl-1-vinyl-cyclohex-3-enyl]-acetamide 
• 1026684-08-1 2,2,2-Trichloro-N-[(1R,2S)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-5,6-dioxo-1-vinyl-cyclohex-3-enyl]-acetamide 

Downstream Products

• 444681-02-1 Acetic acid (1R,4S,6R,7R,8R,9S,10S,11S)-10,11-diacetoxy-8-(3-benzyl-ureido)-6-methoxy-11-methyl-3-oxo-2,5-dioxa-tricyclo[5.4.0.0^4,8]undec-9-yl ester 
• 4368-28-9 tetradotoxin 
• 794568-19-7 2,2,2-Trichloro-N-[(1R,2S,5R,6S)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-hydroxymethyl-5,6-bis-triethylsilanyloxy-1-vinyl-cyclohex-3-enyl]-acetamide 

Relevant academic research and scientific papers

Asymmetric total synthesis of 11-deoxytetrodotoxin,a naturally occurring congener

Tetrodotoxin, a toxic principle of puffer fish poisoning, is a specific blocker of sodium channel. Despite many synthetic efforts since the structure elucidation in 1964, the only total synthesis of the racemic tetrodotoxin has been reported by Kishi and