444711-08-4Relevant articles and documents
Synthesis of substituted 2,3-dihydrobenzofuran in a process involving a facile acyl migration
Li, Wen-Sen,Guo, Zhenrong,Thornton, John,Katipally, Kishta,Polniaszek, Richard,Thottathil, John,Vu, Truc,Wong, Michael
, p. 1923 - 1925 (2007/10/03)
Reduction of 2,6-diacetoxy-2′-bromoacetophenone (10) with NaBH4 led to 3,4-diacetoxydihydrobenzofuran (12) in a process involving acyl migration followed by cyclization. Subsequent hydrogenolysis gave 4-acetoxydihydrobenzofuran which, upon saponification, afforded 4-hydroxydihydrobenzofuran (8) in good yield. This approach is shown to be a general method for preparation of substituted dihydrobenzofurans.