444727-12-2Relevant academic research and scientific papers
LPXH TARGETING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME
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, (2021/04/17)
LpxH targeting compounds, compositions thereof, as well as methods for for making and using the same are disclosed herein. The LpxH target compounds typically have a structure pursuant to Formula (I) and/or a salt thereof, wherein Rb is selecte
Synthesis and evaluation of sulfonyl piperazine LpxH inhibitors
Ennis, Amanda F.,Fenton, benjamin A.,Hong, Jiyong,Kwak, Seung-Hwa,Lim, Won Young,Webster, caroline G.,Zhou, Pei,cho, Jae,cochrane, c. Skyler
, (2020/07/13)
The UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH is essential in lipid A biosynthesis and has emerged as a promising target for the development of novel antibiotics against multidrug-resistant Gram-negative pathogens. Recently, we reported the c
HETEROCYCLIC COMPOUND
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, (2016/04/08)
The present invention relates to a compound represented by the formula (I), which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. In the formula (I), each symbol is as defined in the specification.
Polymers based on N-carbamyl-N'-dimethysilyl methyl-piperazine traceless linkers for the solid phase synthesis of phenyl based libraries
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, (2008/06/13)
The present invention relates to polymers characterized by novel silicon linkers based on the carbamyl piperazine moiety, methods of preparing these polymers and their use in the solid phase synthesis of compounds or libraries of compounds embracing a phenyl ring in their structure.
