2,3-DIMETHYL-6-NITRO-2H-INDAZOLE is an organic compound that serves as an impurity in the synthesis of Pazopanib (P210925) hydrochloride, which is an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
444731-73-1
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Basic information
- Product Name: 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE
- Synonyms: 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE;2,3-dimethyl-6-nitro-1H-indazole;2,3-Dimethyl-6-nitro-1H-i...;2H-Indazole, 2,3-diMethyl-6-nitro-;3-Methly-6-nitroindazole;3-diMethyl-6-nitro-2H-indazole;Pazopanib Impurity 5
- CAS NO:444731-73-1
- Molecular Formula: C9H9N3O2
- Molecular Weight: 191.19
- EINECS: 1592732-453-0
- Product Categories: N/A
- Mol File: 444731-73-1.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 377.033°C at 760 mmHg
- Flash Point: 181.824°C
- Appearance: /
- Density: 1.37g/cm3
- Vapor Pressure: 0mmHg at 25°C
- Refractive Index: 1.655
- Storage Temp.: Sealed in dry,Room Temperature
- Solubility: DMSO (Slightly), Methanol (Slightly)
- PKA: -0.55±0.30(Predicted)
- CAS DataBase Reference: 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE(CAS DataBase Reference)
- NIST Chemistry Reference: 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE(444731-73-1)
- EPA Substance Registry System: 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE(444731-73-1)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 444731-73-1(Hazardous Substances Data)
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444731-73-1 Usage
Uses
Used in Pharmaceutical Industry:2,3-DIMETHYL-6-NITRO-2H-INDAZOLE is used as an impurity in the synthesis of Pazopanib (P210925) hydrochloride for its role in targeting VEGFR and PDGFR, which are essential in the development of various types of cancer. Its presence in the synthesis process may affect the efficacy and safety of the final drug product, making it a significant consideration in the development and production of Pazopanib hydrochloride.
Check Digit Verification of cas no
The CAS Registry Mumber 444731-73-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,4,7,3 and 1 respectively; the second part has 2 digits, 7 and 3 respectively.Calculate Digit Verification of CAS Registry Number 444731-73:
(8*4)+(7*4)+(6*4)+(5*7)+(4*3)+(3*1)+(2*7)+(1*3)=151
151 % 10 = 1
So 444731-73-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H9N3O2/c1-6-8-4-3-7(12(13)14)5-9(8)10-11(6)2/h3-5H,1-2H3
444731-73-1Upstream product
444731-73-1Downstream Products
- 444731-75-3 N-(2-chloropyrimidin-4-yl)-N-methyl-2,3-dimethyl-2H-indazole-6-amine
- 635702-64-6 pazopanib hydrochloride
- 444731-52-6 pazopanib
- 1376676-65-1 N,2,3-trimethyl-2H-indazole-6-amine
- 1620059-11-1 5-[[4-[N-(2,3-dimethyl-2H-indazol-6-yl)-N-methylamino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]-2-methyl-benzenesulfonamide
- 1620843-77-7 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)amino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]-2-methyl-benzenesulfonamide
- 1620059-12-2 3-[[4-[N-(2,3-dimethyl-2H-indazol-6-yl)-N-methylamino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]-benzenesulfonamide
- 1620843-78-8 3-[[4-[(2,3-dimethyl-2H-indazol-6-yl)amino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]-benzenesulfonamide
- 1620843-79-9 3-[[4-[N-(2,3-dimethyl-2H-indazol-6-yl)-N-methylamino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]-4-methoxy-benzenesulfonamide
- 1620059-14-4 N2-(3,4-dimethoxyphenyl)-N4-(2,3-dimethyl-2H-indazol-6-yl)-N4-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine
- 1620059-15-5 N2-(3-bromohenyl)-N4-(2,3-dimethyl-2H-indazol-6-yl)-N4-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine
- 1620059-16-6 N4-(2,3-dimethyl-2H-indazol-6-yl)-N2-(3-fluorohenyl)-N4-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine
- 1620843-80-2 5-[[4-[N-(2,3-dimethyl-2H-indazol-6-yl)-N-methylamino]-5,6,7,8-tetrahydroquinazolin-2-yl]amino]-2-methyl-benzenesulfonamide
- 1620843-82-4 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)amino]-5,6,7,8-tetrahydroquinazolin-2-yl]amino]-2-methyl-benzenesulfonamide
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2,3-DIMETHYL-6-NITRO-2H-INDAZOLE
