444804-80-2Relevant academic research and scientific papers
Syntheses of heterocyclic ethenyl C-nucleosides for recognition of inverted base pairs within the DNA triple helix by stereoselective intramolecular cyclization and olefin metathesis
Rothman, Jeffrey H.
supporting information; experimental part, p. 925 - 928 (2009/06/20)
Canonical recognition of gene sequences would allow precise means for specific genetic intervention. Unfortunately, specific recognition of two of the four possible base pairs by triplex-forming oligonucleotide (TFO) as X ? T-A and Y ? C-G within a triple
Synthesis of medium-ring lactones via tandem methylenation/Claisen rearrangement of cyclic carbonates
Anderson, Edward A,Davidson, James E.P,Harrison, Justin R,O'Sullivan, Paul T,Burton, Jonathan W,Collins, Ian,Holmes, Andrew B
, p. 1943 - 1971 (2007/10/03)
The conversion of vinyl-substituted 6- and 7-membered cyclic carbonates into 8- and 9-membered medium-ring lactones has been achieved in good yield using dimethyltitanocene in toluene at reflux. The reaction proceeds by initial formation of a ketene acetal which undergoes subsequent in situ Claisen rearrangement to provide the corresponding lactones. The preparation of the cyclic carbonates is carried out under basic conditions and hence this methodology complements our existing selenium-based methodology for the synthesis of medium-ring lactones.
