444814-17-9

Basic information

• Product Name: 2-(2-chlorophenyl)-5-methyl-4H-chromen-4-one
• Synonyms: 2-(2-chlorophenyl)-5-methyl-4H-chromen-4-one
• CAS NO: 444814-17-9
• Molecular Weight: 270.715
• Mol File: 444814-17-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-chlorophenyl)-5-methyl-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-chlorophenyl)-5-methyl-4H-chromen-4-one(444814-17-9)
• EPA Substance Registry System: 2-(2-chlorophenyl)-5-methyl-4H-chromen-4-one(444814-17-9)

Safety Data

• Hazardous Substances Data: 444814-17-9(Hazardous Substances Data)

Upstream product

• 609-65-4 o-chlorobenzoyl chloride 
• 41085-27-2 2'-hydroxy-6'-methylacetophenone 
• 1025952-31-1 1-(2-chloro-phenyl)-3-(2-hydroxy-6-methyl-phenyl)-propane-1,3-dione 

Relevant articles and documents

Novel, non-acylguanidine-type Na+/H+ exchanger inhibitors: Synthesis and pharmacology of 5-tetrahydroquinolinylidene aminoguanidine derivatives

In the course of our research into new types of non-acylguanidine Na+/H+ exchanger (NHE) inhibitors, we designed and synthesized aryl-fused tetrahydropyranylidene and cyclohexylidene aminoguanidine derivatives I (X = O, CH2), which were tested for their inhibitory effects on rat platelet NHEs. After optimization, we found that the S isomer of tetrahydroquinoline derivatives that possess a methyl group in the 4-position and a halogen or methyl group in the o-position of Ar2 exhibited high inhibitory activity. In these compounds, (5E,7S)-[[7-(5-fluoro-2-methylphenyl)-4-methyl-7,8-dihydro-5(6H) -quinolinylidene]amino]guanidine dimethane-sulfonate (18, T-162559) was found to be a potent inhibitor of both rat and human platelet NHEs, with IC50 values of 14 and 13 nM, respectively. Furthermore, in a rat myocardial infarction model in vivo (1 h ischemia-24 h reperfusion), 18 (0.1 mg/kg, intravenously administered 5 min or 2 h before coronary occlusion) showed significant activity (33% or 23% inhibition, respectively). These results suggested that 18 may exhibit a potent and long-lasting protective activity against cardiac injuries induced by ischemia-reperfusion.