444884-33-7

Upstream product

• 444884-29-1 (R)-4-{(2R,5R)-5-[(R)-3-((4R,5R)-5-But-3-enyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-iodo-propyl]-tetrahydro-furan-2-yl}-2,2-dimethyl-[1,3]dioxepane 
• 444884-30-4 (R)-1-{(2R,5R)-5-[(R)-3-((4R,5R)-5-But-3-enyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-iodo-propyl]-tetrahydro-furan-2-yl}-butane-1,4-diol 
• 444884-31-5 (2R,5R,2'R)-5-[(R)-3-((4R,5R)-5-But-3-enyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-iodo-propyl]-octahydro-[2,2']bifuranyl 
• 221367-57-3 3-((4R,5R)-5-{(R)-3-[(2R,5R)-5-((R)-2,2-Dimethyl-[1,3]dioxepan-4-yl)-tetrahydro-furan-2-yl]-3-iodo-propyl}-2,2-dimethyl-[1,3]dioxolan-4-yl)-propan-1-ol 
• 444884-35-9 3-((4R,5R)-5-{(R)-3-[(2R,5R)-5-((R)-2,2-Dimethyl-[1,3]dioxepan-4-yl)-tetrahydro-furan-2-yl]-3-iodo-propyl}-2,2-dimethyl-[1,3]dioxolan-4-yl)-propionaldehyde 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 444884-32-6 (R)-(2S,5R,2'R,5'R,2''R)-1-(Dodecahydro-[2,2';5',2'']terfuran-5-yl)-pent-4-en-1-ol 

Downstream Products

• 444884-36-0 (R)-4-(tert-Butyl-diphenyl-silanyloxy)-4-(2S,5R,2'R,5'R,2''R)-dodecahydro-[2,2';5',2'']terfuran-5-yl-butyric acid 

Relevant academic research and scientific papers

1,2-O-Isopropylidene-5-alkene templates for the synthesis of oligo-tetrahydrofurans

The highly functionalized THF 4 was prepared in eight steps from 2,5-cyclooctadiene. The key step in this synthesis was a novel desymmetrization reaction involving the iodoetherification of the C2 symmetric bis-isopropylidene alkene 6 to THF 4. The versatility of 4 was demonstrated by its conversion to bis-THF 3, a known precursor for trilobacin, and to the tris-THF-lactone 5, a potential relay compound for cyclic polyether analogues.