444884-76-8Relevant academic research and scientific papers
Stereoselective synthesis of Ψ[CH2O] pseudodipeptides and conformational analysis of a PheΨ[CH2O]Ala containing analogue of the drug desmopressin
Hedenstr?m, Mattias,Holm, Lotta,Yuan, ZhongQing,Emten?s, Hans,Kihlberg, Jan
, p. 841 - 844 (2002)
A method for the synthesis of XaaΨ[CH2O]Ala/Gly pseudodipeptides in good yields and excellent diastereoselectivity from azido alcohols and (R)-2-chloropropionic acid or tert-butyl bromoacetate has been developed. Insertion of one of the pseudodipeptide building blocks in the peptide drug desmopressin revealed that methylene either isosteres may have only a minor influence on the secondary structure of peptides.
