4449-45-0Relevant academic research and scientific papers
SUBSTITUTED TRIAZINONES AS THYROID HORMONE RECEPTOR AGONISTS
-
Paragraph 00178; 00181, (2021/07/24)
The application relates to a compound of Formula (I') or (I), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of thyroid hormone receptors, a pharmaceutical composition comprising a compound of Formula (I') or (I), and a method of treating or preventing a disease or disorder regulated by thyroid hormone.
Analysis of an Active Deformylation Mechanism of 5-Formyl-deoxycytidine (fdC) in Stem Cells
Sch?n, Alexander,Kaminska, Ewelina,Schelter, Florian,Ponkkonen, Eveliina,Korytiaková, Eva,Schiffers, Sarah,Carell, Thomas
supporting information, p. 5591 - 5594 (2020/03/04)
The removal of 5-methyl-deoxycytidine (mdC) from promoter elements is associated with reactivation of the silenced corresponding genes. It takes place through an active demethylation process involving the oxidation of mdC to 5-hydroxymethyl-deoxycytidine
Synthesis and Antiviral Properties of 5-(2-Substituted vinyl)-6-aza-2'-deoxyuridines
Mitchell, William L.,Ravenscroft, Paul,Hill, Malcolm L.,Knutsen, Lars J.S.,Judkins, Brian D.,et al.
, p. 809 - 816 (2007/10/02)
The following 5-(2-substituted vinyl)-6-aza-2'-deoxyuridines were synthesized: (E)-5-(2-bromovinyl) (2) (6-aza-BVDU), 5-(2-bromo-2-fluorovinyl) (a mixture E and Z isomers) (3), (E)-5-(2-chlorovinyl) (4), (E)-5- (5), 5-(2,2-dibromoviny
