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Usage

Uses

Used in Pharmaceutical Industry:
ANAGRELIDE IMPURITY 5 is used as an antithrombocythemic agent for the treatment of thrombocythemia, a condition characterized by an abnormally high number of platelets in the blood. It helps in reducing the platelet count, thereby mitigating the risk of blood clot formation and associated complications.

Upstream product

• 506-68-3 bromocyane 
• 147249-42-1 6-amino-2,3-dichlorobenzylamine 

Downstream Products

• 733043-41-9 6,7-dichloro-3-hydroxy-1,5-dihydro-imidazo[2,1-b]quinazolin-2-one 
• 2387-23-7 1,3-Dicyclohexylurea 
• 875467-37-1 C₁₄H₁₅Cl₂N₃O₃ 

Relevant academic research and scientific papers

Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Structure-activity relationship elucidation

The optimisation of affinity and selectivity in a novel series of dual 5-HT5A/5-HT7 receptor ligands is described. Brain penetrant 2-aminodihydroquinazolines with low nanomolar affinities were identified.

2-amino-5,6-dichloro-3,4-dihydroquinazoline, its method of making and using and pharmaceutical compositions thereof

The compound 2-amino-5,6-dichloro-3,4-dihydroquinazoline has been found to have enhanced platelet count reducing properties. Also provided are methods for synthetically making the compound and a method of reducing the platelet count in a patient by administering to the patient a platelet reducing effective amount of the compound preferably together with a pharmaceutically acceptable carrier. A pharmaceutical composition is also provided which contains the above compound as the active ingredient together with pharmaceutically acceptable excipients.