444912-53-2 Usage
Uses
Used in Pharmaceutical Industry:
Methanone, (2-iodo-5-nitrophenyl)[1-[[(2S)-1-methyl-2-piperidinyl]methyl]-1H-indol-3-yl]-, is used as a synthetic cannabinoid for its agonist activity on the CB2 receptor. This application is significant due to its potential therapeutic effects in various medical conditions, such as pain management, inflammation, and neuroprotection.
Used in Research and Development:
In the field of research and development, Methanone, (2-iodo-5-nitrophenyl)[1-[[(2S)-1-methyl-2-piperidinyl]methyl]-1H-indol-3-yl]-, serves as an important compound for studying the effects and mechanisms of action of CB2 receptor agonists. This knowledge can be utilized to develop new drugs and therapies targeting the CB2 receptor for various medical applications.
Used in Drug Synthesis:
Methanone, (2-iodo-5-nitrophenyl)[1-[[(2S)-1-methyl-2-piperidinyl]methyl]-1H-indol-3-yl]-, can be used as a key intermediate in the synthesis of other cannabinoid-related compounds. Its unique structure and properties make it a valuable building block for creating novel synthetic cannabinoids with potential applications in various industries.
Used in Drug Delivery Systems:
Similar to gallotannin, Methanone, (2-iodo-5-nitrophenyl)[1-[[(2S)-1-methyl-2-piperidinyl]methyl]-1H-indol-3-yl]-, may also benefit from novel drug delivery systems to enhance its bioavailability and therapeutic outcomes. Researchers can explore the use of various organic and metallic nanoparticles as carriers for improved delivery and efficacy of this synthetic cannabinoid.
Check Digit Verification of cas no
The CAS Registry Mumber 444912-53-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,4,9,1 and 2 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 444912-53:
(8*4)+(7*4)+(6*4)+(5*9)+(4*1)+(3*2)+(2*5)+(1*3)=152
152 % 10 = 2
So 444912-53-2 is a valid CAS Registry Number.
444912-53-2Relevant academic research and scientific papers
In vitro pharmacological characterization of AM1241: A protean agonist at the cannabinoid CB2 receptor?
Yao,Mukherjee,Fan,Garrison,Daza,Grayson,Hooker,Dart,Sullivan,Meyer
, p. 145 - 154 (2007/10/03)
Background and purpose: The CB2 receptor has been proposed as a novel target for the treatment of pain, and CB2 receptor agonists defined in in vitro assays have demonstrated analgesic activity in animal models. Based on its in vivo analgesic efficacy, AM1241 has been classified as a CB2-selective agonist. However, in vitro characterization of AM1241 in functional assays has not been reported. Experimental approach: In this study, AM1241 was characterized across multiple in vitro assays employing heterologous recombinant receptor expression systems to assess its binding potencies at the human CB2 and CB1 receptors and its functional efficacies at the human CB2 receptor. Key results: AM1241 exhibited distinct functional properties depending on the assay conditions employed, a unique profile in contrast to those of the agonist CP 55,940 and the inverse agonist SR144528. AM1241 displayed neutral antagonist activities in FLIPR and cyclase assays. However, when cyclase assays were performed using lower forskolin concentrations for stimulation, AM1241 exhibited partial agonist efficacy. In addition, it behaved as a partial agonist in ERK (or MAP) kinase assays. Conclusions and implications: The unusual phenomenon of inconsistent functional efficacies suggests that AM1241 is a protean agonist at the CB 2 receptor. We postulate that functional efficacies displayed by protean agonists in various assay systems may depend on the levels of receptor constitutive activities exhibited in the assay systems, and therefore, efficacies observed in in vitro assays may not predict in vivo activities.
