445-15-8

Basic information

• Product Name: benzenesulfonyl fluoride, 2,4-dimethyl-
• Synonyms: 2,4-Dimethylbenzenesulfonyl fluoride
• CAS NO: 445-15-8
• Molecular Formula: C₈H₉FO₂S
• Molecular Weight: 188.2193
• Mol File: 445-15-8.mol

Chemical Properties

• Boiling Point: 242.524°C at 760 mmHg
• Flash Point: 100.475°C
• Density: 1.233g/cm³
• Vapor Pressure: 0.053mmHg at 25°C
• Refractive Index: 1.5
• CAS DataBase Reference: benzenesulfonyl fluoride, 2,4-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: benzenesulfonyl fluoride, 2,4-dimethyl-(445-15-8)
• EPA Substance Registry System: benzenesulfonyl fluoride, 2,4-dimethyl-(445-15-8)

Safety Data

• Hazardous Substances Data: 445-15-8(Hazardous Substances Data)

Upstream product

• 108-38-3 m-xylene 
• 68978-26-7 m-xylene-4-sulfonic acid, potassium salt 
• 88-61-9 2,4-dimethylbenzenesulfonic acid 
• 827-21-4 m-xylene-4-sulphonic acid sodium salt 
• 7789-21-1 fluorosulphonic acid 
• 201230-82-2 carbon monoxide 

Downstream Products

• 39153-54-3 bis-(2,4-dimethyl-benzenesulfonyl)-methane 
• 70265-10-0 5-methyl-3H-benzo[c][1,2]oxathiole-1,1-dioxide 

Relevant articles and documents

Facile one-pot synthesis of sulfonyl fluorides from sulfonates or sulfonic acids

A facile cascade process for directly transforming the abundant and inexpensive sulfonates (or sulfonic acids) to the highly valuable sulfonyl fluorides was developed. This new protocol features mild reaction conditions using readily available and easy-to-operate reagents. A diverse set of sulfonyl fluorides was prepared facilitating the enrichment of the sulfonyl fluoride library.

Formylation of Aromatic Compounds with CO in HSO3F-SbF5 under Atmospheric Pressure

The formylation of aromatic compounds such as benzene, toluene, xylenes, mesitylene, indan, tetralin, fluorobenzene, chlorobenzene, and bromobenzene was carried out in HSO3F-SbF5 under atmospheric CO pressure at 0 deg C.In HSO3F-SbF5, both formylation and sulfonation took place to give formyl and sulfonyl compounds.In the case of alkylbenzenes, including toluene, xylenes, mesitylene, and tetralin, formylalkylbenzenesulfonyl fluorides, new compounds, were obtained by a one-pot reaction as well as alkylbenzaldehydes, alkylbenzenesulfonyl fluorides, and bis(alkylphenyl) sulfones.The direct introduction of a formyl and sulfonyl group was achieved in alkylbenzenes.The reaction path of the new compounds is a two-step reaction comprised of formylation as the first step and sulfonation as the second step.The product composition was strongly dependent on the acid strength of the HSO3F-SbF5 systems.The formyl compounds became predominant with increasing acidity of the HSO3F-SbF5 system.On the other hand, only sulfonyl compounds were produced when the acidity of the HSO3F-SbF5 system was low.

OXIDATION OF METHYL-SUBSTITUTED BENZENESULFONYL FLUORIDES IN THE PbO2-HSO3F SYSTEM

The transformations of the sulfonyl fluorides of methyl-substituted benzenes in the PbO2-HSO3F system were studied.They take place through a stage involving the one-electron oxidation of the substrate to aromatic radical-cations.One of the transformation paths of the latter is realized through the elimination of a proton from the methyl groups involved to the greatest degree in the delocalization of the unpaired electron.This leads to the formation of diarylmethanes and the fluorosulfonates of substituted benzyl alcohols, which give substituted tolylsultones and benzyl alcohols during hydrolysis of the acid solution and methyl ethers of benzyl alcohols during methanolysis.The other path, which arises during localization of the unpaired electron in the unsubstituted positions of the benzene ring, leads to biaryls.