445-38-5

Usage

Appearance

Yellow-orange pigment

Source

Found in turmeric, a spice and food coloring

Medicinal properties

a. Anti-inflammatory
b. Antioxidant
c. Anti-cancer

Potential health applications

a. Arthritis treatment
b. Diabetes management
c. Cardiovascular disease prevention

Research status

Promising results in preclinical and clinical studies

Field of interest

Medicine and pharmacology

Upstream product

• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 1996-41-4 2-chloro-4-fluorophenol 
• 108-24-7 acetic anhydride 
• 459-60-9 1-fluoro-4-methoxybenzene 

Downstream Products

• 16108-84-2 1-(4-Acetamino-benzolsulfonylhydrazono)-1-(5-fluor-3-chlor-2-hydroxy-phenyl)-ethan 
• 1245737-91-0 8-chloro-6-fluoro-N-[4-(trifluoromethyl)phenyl]-3,4-dihydrospiro[chromene-2,4'-piperidine]-1'-carboxamide 

Relevant academic research and scientific papers

COMPOUND USED AS KINASE INHIBITOR AND APPLICATION THEREOF

Provided is the compound represented by formula I, or tautomer thereof, or meso thereof, racemate thereof, and mixture of meso and racemate thereof, or enantiomer thereof, diastereomer, and mixture of enantiomer and diastereomer, or pharmaceutically acceptable salt thereof, or deuterate thereof. The compound of formula I can be used as a kinase inhibitor, as a drug for the treatment of ROS1, NTRK, ALK and other kinase-mediated diseases.

N-CONTAINING CHROMEN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The present invention provides the compounds having the general formula: (I) wherein R1 to R8, and X are as described herein, compositions including the compounds and methods of using the compounds.

FLAVONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE

The present invention provides flavone derivatives having the general formula (I) which are useful for the treatment of Hepatitis B Virus infection (HBV). The compounds act as cccDNA (covalently closed circular DMA) inhibitors.

CHROMAN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The present invention provides compounds having the general formula (I) wherein R1 to R10, Gi, G2, X and m are as described herein, compositions including the compounds and methods of using the compounds for treating hepatitis B.