445007-02-3

Basic information

• Product Name: 3-hydroxy-3-(2-iodophenyl)-2,2-dimethylpropanenitrile
• Synonyms: 3-hydroxy-3-(2-iodophenyl)-2,2-dimethylpropanenitrile
• CAS NO: 445007-02-3
• Molecular Weight: 301.127
• Mol File: 445007-02-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-3-(2-iodophenyl)-2,2-dimethylpropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-3-(2-iodophenyl)-2,2-dimethylpropanenitrile(445007-02-3)
• EPA Substance Registry System: 3-hydroxy-3-(2-iodophenyl)-2,2-dimethylpropanenitrile(445007-02-3)

Safety Data

• Hazardous Substances Data: 445007-02-3(Hazardous Substances Data)

Upstream product

• 26260-02-6 2-iodobenzaldehyde 
• 495414-24-9 3-(2-iodophenyl)-2,2-dimethyl-3-(trimethylsilyloxy)propanenitrile 

Downstream Products

• 495414-26-1 3-acetoxy-3-(2-iodophenyl)-2,2-dimethylpropanenitrile 
• 495414-25-0 3-(2-iodophenyl)-3-methoxy-2,2-dimethylpropanenitrile 
• 59269-93-1 3-hydroxy-2,2-dimethylindan-1-one 
• 50654-42-7 3-hydroxy-2,2-dimethyl-3-phenylproprionitrile 

Relevant articles and documents

Carbopalladation of nitriles: Synthesis of benzocyclic ketones and cyclopentenones via Pd-catalyzed cyclization of ω-(2-iodoaryl)alkanenitriles and related compounds

An efficient procedure for the synthesis of 2,2-disubstituted benzocyclic ketones by intramolecular carbopalladation of nitriles has been developed. The cyclization of substituted 3-(2-iodoaryl)-propanenitriles affords indanones in high yields. The reaction is compatible with a wide variety of functional groups. This methodology has been extended to the synthesis of tetralones and cyclopentenones.