4452-45-3Relevant academic research and scientific papers
Biological Investigations of (+)-Danicalipin A Enabled Through Synthesis
Bailey, Adrian M.,Wolfrum, Susanne,Carreira, Erick M.
supporting information, p. 639 - 643 (2016/02/27)
A total synthesis of the chlorosulfolipid (+)-danicalipin A has been accomplished in 12 steps and 4.4 % overall yield. The efficient and scalable synthesis enabled in-depth investigations of the lipid's biological properties, in particular cytotoxicity towards various mammalian cell lines. Furthermore, the ability of (+)-danicalipin A to increase the uptake of fluorophores into bacteria and mammalian cells was demonstrated, indicating it may enhance membrane permeability. By comparing (+)-danicalipin A with racemic 1,14-docosane disulfate, and the diol precursor of (+)-danicalipin A, we have shown that both chlorine and sulfate functionalities are necessary for biological activity.
Improved method for the selective conversion of aliphatic esters to alcohols by zinc borohydride in tetrahydrofuran
Narasimhan, S,Palmer, Prem
, p. 701 - 702 (2007/10/02)
Selective conversion of aliphatic esters to the corresponding alcohols has been achieved in excellent yields by zinc borohydride in tetrahydrofuran under mild conditions (67 deg C, 6 hr).Unsaturated esters produce the corresponding diols.
