445220-96-2Relevant academic research and scientific papers
Diastereoselective enzymatic synthesis of highly substituted 3,4-dihydropyridin-2-ones via domino Knoevenagel condensation-Michael addition-intramolecular cyclization
Liu, Zhi-Qiang,Liu, Bo-Kai,Wu, Qi,Lin, Xian-Fu
, p. 9736 - 9740 (2011)
A direct method to construct 3,4-dihydropyridin-2-ones by enzymatic condensation of aldehyde with cyanoacetamide and 1,3-dicarbonyl compounds was developed. One ring and four new bonds (two C-C, one C-N, one CC) were formed in one pot. And reaction condit
Synthesis of 3,4-dihydropyridin-2-one derivatives in convergent mode applying bio catalyst vitamin B1 and polymer supported catalyst PEG-SO3H from two different sets of building blocks
Pradhan, Koyel,Bhattacharyya, Pranabes,Paul, Sanjay,Das, Asish R.
, p. 5840 - 5844,5 (2020/08/20)
Two highly efficient, green protocols have been developed for the synthesis of 3,4-dihydropyridin-2-one derivatives from different starting materials exploring two reaction specific catalysts, vitamin B1 (VB 1), and PEG-SO3/sub
Nano crystalline ZnO catalyzed one pot multicomponent reaction for an easy access of fully decorated 4H-pyran scaffolds and its rearrangement to 2-pyridone nucleus in aqueous media
Bhattacharyya, Pranabes,Pradhan, Koyel,Paul, Sanjay,Das, Asish R.
supporting information; experimental part, p. 4687 - 4691 (2012/09/05)
A green and highly efficient protocol has been developed for the synthesis of 4H-pyran scaffolds installing a one-pot three-component coupling reaction of an aldehyde, malononitrile, and a 1,3-diketo compound using nano structured ZnO as the catalyst in a
Imidazole-catalyzed three-component cascade reaction for the facile synthesis of highly substituted 3,4-dihydropyridin-2-one derivatives
Liu, Zhiqiang,Tan, Lu,Wu, Qi,Lin, Xianfu
, p. 2343 - 2348,6 (2012/12/12)
A novel one-pot protocol for the synthesis of valuable 3,4-dihydropyridin- 2-ones from the condensation of aldehyde with cyanoacetamide and 1,3-dicarbonyl compounds in the presence of imidazole was developed. A series of aldehydes and 1,3-dicarbonyl compounds were employed to examine the scope of substrates for this protocol. This reaction proceeded through the formation of one ring and four new bonds (two Ci￡C, one Ci￡N, one Ci￡C) via the sequence involving Knoevenagel condensation, Michael addition and intramolecular cyclization with moderate to excellent yields. All new compounds were characterized by IR, 1H NMR, 13C NMR and HRMS. Copyright
