445221-18-1

Basic information

• Product Name: N-methyl-2-(4-phenyl-1,3-thiazol-2-yl)acetamide
• CAS NO: 445221-18-1
• Molecular Weight: 232.306
• Mol File: 445221-18-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-methyl-2-(4-phenyl-1,3-thiazol-2-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-2-(4-phenyl-1,3-thiazol-2-yl)acetamide(445221-18-1)
• EPA Substance Registry System: N-methyl-2-(4-phenyl-1,3-thiazol-2-yl)acetamide(445221-18-1)

Safety Data

• Hazardous Substances Data: 445221-18-1(Hazardous Substances Data)

Upstream product

• 59749-86-9 N-methyl-2-thiocarbamoylacetamide 
• 2700-22-3 Benzylidenemalononitrile 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 1025796-00-2 2-amino-1-methyl-6-oxo-4-phenyl-5-(4-phenyl-1,3-thiazol-2-yl)-1,6-dihydropyridine-3-carbonitrile 

Relevant articles and documents

Alternative products in one-pot reaction of benzylidenemalononitrile, N-methyl-2-thiocarbamoylacetamide, and ω-bromoacetophenone

N-Methyl-2-benzoylmethylsulfanyl-4-phenylnicotinamide and N-methyl-2-(4-phenyl-1,3-thiazol-2-yl)-acetamide have been obtained as alternative products to the desired N-methyl-2,3-dihydro-7H-thiazolo[3,2-a] pyridine-8-carboxamide by a one-pot cyclocondensation of benzylidenemalononitrile, N-methyl-2-thiocarbamoylacetamide, piperidine, and ω-bromoacetophenone. 2-Amino-1-methyl-6-oxo-4-phenyl-5-(4-phenyl-1,3- thiazol-2-yl)-1,6-dihydropyridine-3-carbonitrile has been obtained as main product by treatment of benzylidenemalononitrile with N-methyl-2-(1,3-thiazol-2- yl)acetamide.