445223-06-3Relevant academic research and scientific papers
Site-specific role of bifunctional graphitic carbon nitride catalyst for the sustainable synthesis of 3,3-spirocyclic oxindoles in aqueous media
Dandia, Anshu,Mahawar, Dinesh Kumar,Saini, Pratibha,Saini, Surendra,Gupta, Shyam L.,Rathore, Kuldeep S.,Parewa, Vijay
, p. 28452 - 28465 (2021/09/22)
Functionalized graphitic carbon nitride (Sg-C3N4) has been manufactured and used as a reusable catalyst for the one-pot production of various spiro-pyrano chromenes and spiro indole-3,1′-naphthalene tetracyclic systems in aqueous med
Enantioselective assembly of functionalized carbocyclic spirooxindoles using an L-proline derived thiourea organocatalyst
Reddy Gajulapalli, V. Pratap,Vinayagam, Poopathy,Kesavan, Venkitasamy
, p. 7370 - 7379 (2015/03/05)
Sequential vinylogous Michael addition-cyclization reactions of vinyl malononitriles with isatylidene malononitrile were accomplished using l-proline derived bifunctional thiourea. Cyclohexylidine malononitrile afforded exclusively the single diastereomer
Organocatalytic enantioselective construction of multi-functionalized spiro oxindole dienes
Huang, Xiao-Fei,Zhang, Ya-Fei,Qi, Zheng-Hang,Li, Nai-Kai,Geng, Zhi-Cong,Li, Kun,Wang, Xing-Wang
, p. 4372 - 4385 (2014/06/23)
A diastereo- and enantio-selective domino Michael-cyclization- tautomerization reaction of isatylidene malononitriles with α,α- dicyanoalkenes catalyzed by a cinchona alkaloid-derived bifunctional thiourea catalyst has been developed. A series of multi-functionalized spiro oxindole diene derivatives have been obtained in good to excellent yields (up to 97%) with good to excellent enantioselectivities (up to 96%) as well as good diastereoselectivities (up to 7.9=1). In addition, an anomalous temperature effect on the enantioselectivity has also been studied for this transformation. the Partner Organisations 2014.
A novel method for the synthesis of functionalized spirocyclic oxindoles by one-pot tandem reaction of vinyl malononitriles with isatylidene malononitriles
Hari Babu, Thelagathoti,Abragam Joseph,Muralidharan,Perumal, Paramasivan T.
experimental part, p. 994 - 996 (2010/05/03)
One-pot synthesis of novel spirocyclic oxindoles was achieved via vinylogous Michael addition of vinyl malononitriles on isatin-malononitrile adducts as the key step followed by a sequential tandem reaction.
