445249-31-0Relevant academic research and scientific papers
3′-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase
Vanheusden, Veerle,Munier-Lehmann, Hélène,Froeyen, Matheus,Dugué, Laurence,Heyerick, Arne,De Keukeleire, Denis,Pochet, Sylvie,Busson, Roger,Herdewijn, Piet,Van Calenbergh, Serge
, p. 3811 - 3821 (2007/10/03)
Thymidine monophosphate kinase (TMPK) of Mycobacterium tuberculosis (TMPKmt) represents an attractive target for blocking the bacterial DNA synthesis. In an attempt to find high-affinity inhibitors of TMPKmt, a cavity in the enzyme at the 3′-position was
