445291-65-6

Upstream product

• 213273-03-1 4-oxo-2-(N-phenyl)amino-4H-chromene-3-carbaldehyde 
• 100-46-9 benzylamine 
• 445291-56-5 2-(N-methyl-N-phenyl)aminochromone-3-carboxaldehyde 

Downstream Products

• 547741-55-9 2-{benzyl[(2E)-but-2-enyl]amino}-4-oxo-4H-1-benzopyran-3-carboxaldehyde 
• 547741-59-3 ethyl (2E)-3-{2-{benzyl[(2E)-3-phenylprop-2-enyl]amino}-4-oxo-4H-1-benzopyran-3-yl}prop-2-enoate 
• 547741-58-2 ethyl (2E)-3-{2-{benzyl[(2E)-but-2-enyl]amino}-4-oxo-4H-1-benzopyran-3-yl}prop-2-enoate 
• 547741-57-1 ethyl (2E)-3-{2-[benzyl(prop-2-enyl)amino]-4-oxo-4H-1-benzopyran-3-yl}prop-2-enoate 
• 547741-69-5 2-[benzyl(methyl)amino]-4-oxo-4H-1-benzopyran-3-carboxaldehyde 
• 547741-54-8 2-[benzyl(prop-2-enyl)amino]-4-oxo-4H-1-benzopyran-3-carboxaldehyde 

Relevant academic research and scientific papers

Pericyclic transformations at the periphery of chromen-4-one (=4H-1-benzopyran-4-one): An unusual preference for a 1,5-shift of allylic moieties over the ene reaction

Quite unlike the reported facile ene reactions on the periphery of many related heterocyclic systems, similarly disposed moieties on the periphery of the chromen-4-one (=4H-1-benzopyran-4-one) system fail to undergo an ene reaction and display a rather un

A versatile route to 2-alkyl-/aryl-amino-3-formyl- and hetero-annelated-chromones, through a facile nucleophilic substitution at C2 in 2-(N-methylanilino)-3-formylchromones

The N-methylanilino group in 2-(N-methylanilino)-3-formylchromones, obtained in high yield by rearrangement of C(4-oxo-4H[1]-benzopyran-3-yl)-N-phenylnitrones to 2-anilino-3-formyl-chromones followed by N-methylation, undergoes facile nucleophilic substitution by a variety of nitrogen nucleophiles, thereby paving the way for synthesis of a variety of novel 2-substituted-3-formylchromone derivatives as well as hetero-annelated chromones.