445292-07-9Relevant academic research and scientific papers
Synthesis and evaluation of pseudopeptide analogues of a specific CXCR4 inhibitor, T140: the insertion of an (E)-alkene dipeptide isostere into the betaII'-turn moiety.
Tamamura, Hirokazu,Hiramatsu, Kenichi,Miyamoto, Kazuhide,Omagari, Akane,Oishi, Shinya,Nakashima, Hideki,Yamamoto, Naoki,Kuroda, Yoshihiro,Nakagawa, Terumichi,Otaka, Akira,Fujii, Nobutaka
, p. 923 - 928 (2007/10/03)
A 14-residue peptide, T140, strongly inhibits the T-cell line-tropic HIV-1 (X4-HIV-1) infection, since this peptide functions as a specific antagonist against a chemokine receptor, CXCR4. T140 takes an antiparallel beta-sheet structure with a type II' bet
