445298-44-2Relevant academic research and scientific papers
Xanthones in heterocyclic synthesis. An efficient and general route for the synthesis of regioselectively substituted phthalazines
Gardikis, Yiannis,Tsoungas, Petros G.,Potamitis, Constantinos,Pairas, George,Zervou, Maria,Cordopatis, Paul
experimental part, p. 1291 - 1302 (2011/06/27)
Xanthone undergoes regioselective substitution and nucleophically - triggered ring opening to the corresponding ketone. Hydrazone of the latter oxidatively rearranges to ortho-diacylarenes, which, then, with hydrazine gives regioselectively substituted phthalazines. Molecular modeling analysis and 1HNMR spectra indicate an intramolecular H-bonding engaging phenol OH and phthalazine N-3 atom.
