445377-33-3Relevant academic research and scientific papers
Nucleic acid derivatives
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, (2008/06/13)
A compound which comprises a backbone having a plurality of chiral carbon atoms, the backbone bearing a plurality of ligands each being individually bound to a chiral carbon atom of the plurality of chiral carbon atoms, the ligands including one or more pair(s) of adjacent ligands each containing a moiety selected from the group consisting of a naturally occurring nucleobase and a nucleobase binding group, wherein moieties of the one or more pair(s) are directly linked to one another via a linker chain; building blocks for synthesizing the compound; and rises of the compound, particularly in antisense therapy.
Enantioselective synthesis of a putative hexaketide intermediate in the biosynthesis of the squalestatins
Simpson, Thomas J.,Smith, Robert W.,Westaway, Susan M.,Willis, Christine L.,Buss, Antony D.,Cannell, Richard J. P.,Dawson, Michael J.,Rudd, Brian A. M.
, p. 5367 - 5370 (2007/10/03)
A convergent synthesis of (3R, 5Z, 8E, 10R)-3-hydroxy-8,10-dimethyl-11-phenylundec-5,8-dienoic acid 4, a putative hexaketide intermediate in the biosynthesis of the squalestatins, is described. A key step in the assembly of the carbon framework is the coupling of alkyne 19 with allylic bromide 13 giving, after further functional group manipulations, the target compound as a single diastereomer. The approach may be adapted for the preparation of the corresponding (3S, 5Z, 8E, 10R)-isomer as well as for the incorporation of carbon-13 labels required for biosynthetic studies.
