445388-25-0Relevant academic research and scientific papers
Differential inhibition of polymerase and strand-transfer activities of HIV-1 reverse transcriptase
Tillekeratne,Sherette, Angela,Fulmer, Jennifer A,Hupe, Lynn,Hupe, Donald,Gabbara, Sam,Peliska, James A,Hudson, Richard A
, p. 525 - 528 (2007/10/03)
A new class of inhibitors of HIV-1 reverse transcriptase obtained by the systematic structural simplification of epicatechin and epigallocatechin gallates are also shown here to inhibit DNA-strand-transfer, a process critical to the completion of the HIV-1-RT reproduction and to recombination-associated mutation of the virus. Up to 80-fold selectivity for DNA-strand-transfer inhibition over polymerase inhibition was observed for a defined subset of these agents. Such specific DNA-strand-transfer inhibitors may have important therapeutic potential.
