445396-74-7

Upstream product

• 1223157-45-6 (S)-3,4-dibromo-5-((R)-hydroxy(phenyl)methyl)furan-2(5H)-one 
• 1223157-56-9 (R)-5-((R)-hydroxy-(phenyl)methyl)-3-phenylthiofuran-2(5H)-one 

Relevant academic research and scientific papers

Asymmetrie direct vinylogous aldol reaction of furanone derivatives catalyzed by an axially chiral guanidine base

Ace of Base: The first highly enantioselectlve direct vinylogous aldol reaction of dihalogenated or α-thio-substituted furanones with aldehydes utilizes an axially chiral guanidine base catalyst. The method provides facile access to enantioenriched γ-subs