445397-17-1

Upstream product

• 102-92-1 Cinnamoyl chloride 
• 445397-14-8 (R)-3-amino-2-[1-(2-hydroxy-ethoxy)-ethyl]-3H-quinazolin-4-one 
• 445397-22-8 (R)-2-(2-benzyloxyethoxy)propionic acid 

Downstream Products

• 445397-20-6 (R)-3-{2-[(R)-1-(2-Hydroxy-ethoxy)-ethyl]-4-oxo-4H-quinazolin-3-ylamino}-3-phenyl-propionic acid methyl ester 
• 445397-19-3 (3R,10R)-10-Methyl-3-phenyl-6,9-dioxa-1,2,12-triaza-tricyclo[9.8.0.0^13,18]nonadeca-11,13⁽¹⁸⁾,14,16-tetraene-5,19-dione 

Relevant academic research and scientific papers

Completely diastereoselective aziridination of α,β-unsaturated acids via intramolecular reaction of 3-acetoxyaminoquinazolin-4(3H)-ones

(R)-3-Amino-2-[1-(2-hydroxyethoxy)ethyl]quinazolin-4(3H)-one 10 was prepared in 62% yield without the need for chromatography and O-cinnamoylated; reaction with lead tetra-acetate gave aziridine 12 as a single diastereoisomer in quantitative yield which was converted into the β-amino acid ester 15 corresponding to overall enantioselective addition of ammonia to the double bond of cinnamic acid.