445455-39-0Relevant academic research and scientific papers
METHOD OF MODULATING NEURITE OUTGROWTH BY THE USE OF A GALANIN-3 RECEPTOR ANTAGONIST
-
Page/Page column 40, (2008/06/13)
The present invention provides methods of modulating neurite outgrowth in an animal. The methods comprise a general administration of galanin-3 receptor antagonists under conditions sufficient to produce neurite outgrowth.
Indolone compounds useful to treat cognitive impairment
-
Page/Page column 11, (2010/11/27)
This invention provides a method of treating a subject suffering from a cognitive impairment or a cognitive disorder which comprises administering to the subject an amount of an indolone compound effective to treat the subject's cognitive impairment or di
Indolone Compounds Useful To Treat Cognitive Impairment
-
Page/Page column 11, (2010/11/27)
This invention provides a method of treating a subject suffering from a cognitive impairment or a cognitive disorder which comprises administering to the subject an amount of an indolone compound effective to treat the subject's cognitive impairment or di
Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility
Konkel, Michael J.,Packiarajan, Mathivanan,Chen, Heidi,Topiwala, Upendra P.,Jimenez, Hermogenes,Talisman, Ian Jamie,Coate, Heather,Walker, Mary W.
, p. 3950 - 3954 (2007/10/03)
A series of amino analogs of 1,3-dihydro-1-phenyl-3-[[3-(trifluoromethyl)phenyl]imino]-2H-indol-2-one (1) were synthesized to improve aqueous solubility, while retaining high affinity for the human galanin Gal3 receptor. A very potent analog (9
GAL3 antagonists for the treatment of neuropathic pain
-
, (2008/06/13)
This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor and are useful for the treatment of neuropathic pain and other abnormalities. This invention also provides a method of treating a subje
USE OF GALR3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF DEPRESSION AND/OR ANXIETY AND COMPOUNDS USEFUL IN SUCH METHODS
-
, (2008/06/13)
This invention is directed to indolone derivatives which are antagonists for the GALR3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier.
GAL3 receptor antagonists for the treatment of affective disorders
-
, (2008/06/13)
This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor. This invention provides a method of treating a subject suffering from an affective disorder which comprises administering to the subje
Use of GAL3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods
-
, (2008/06/13)
This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a
