445466-23-9Relevant academic research and scientific papers
A concise synthesis of 2-(2-aminothiophene)-benzimidazoles by one-pot multicomponent reaction
Chen, Li-Hsun,Chuang, Ying-Sheng,Narhe, Bharat D.,Sun, Chung-Ming
, p. 13934 - 13943 (2013)
A one-pot synthesis of 2-aminothiophene linked benzimidazoles was achieved by utilizing 2-cyanomethyl benzimidazoles in a modified Gewald multicomponent reaction. The synthetic strategy of the reaction involved treatment of 2-(cyanomethyl)-benzimdazole wi
A Novel Mechanistic Study on Ultrasound-Assisted, One-Pot Synthesis of Functionalized Benzimidazo[2,1-b]quinazolin-1(1H)-ones
Chen, Li-Hsun,Chung, Tsai-Wen,Narhe, Bharat D.,Sun, Chung-Ming
, p. 162 - 169 (2016/03/25)
Ultrasound-assisted synthesis of benzimidazo[2,1-b]quinazolin-1(1H)-ones was achieved via piperidine-catalyzed three-component reaction of 2-aminobenzimidazoles, an aromatic aldehyde, and 1,3-dione in aqueous isopropanol. This mechanism was first suspected following our identification of unusual reaction intermediates in a one-pot reaction. An unprecedented coupling reaction, it involved a nucleophilic attack by 2-aminobenzimidazole on in situ generated Michael adduct, followed by electrocyclic ring formation reaction. In contrast to the commonly accepted mechanism, that the direct reaction of 2-amino benzimidazole with a Knoevenagel adduct cannot deliver target compounds.
A facile IL-DMSO assisted synthesis of 5-, 6-, and 7-membered benzo-annelated cyclic guanidines
Verma, Amit,Giridhar, Rajani,Modh, Pratik,Yadav, Mange Ram
, p. 2954 - 2958 (2012/07/28)
A new and facile IL-DMSO assisted method has been developed for the synthesis of biologically important cyclic guanidines like 2-aminobenzimidazole, 2-imino-4-quinazolinone, and 2-imino-5-benzotriazepinones at ambient temperatures. The desired products could be obtained by microwave irradiation32 also, but at elevated temperatures. A plausible mechanism for catalysis has been proposed.
Construction of a Stable Flavin-Gold Electrode displaying Very Fast Electron Transfer Kinetics
Edwards, Timothy R. G.,Cunnane, Vincent J.,Parsons, Roger,Gani, David
, p. 1041 - 1043 (2007/10/02)
The bis-phenylthiourea phenethylisoalloxazine (6) was synthesised and was attached to the gold through its thiourea side-chains; cyclic voltammetric investigation of the redox properties of the system confirmed that the flavin was a stable adsorbed species and revealed that electron transfer between the conductor and the flavin was very fast.
