445474-74-8

Upstream product

• 444615-86-5 2-(tert-butyl-diphenyl-silanyloxymethyl)-6-oxo-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 736180-09-9 (-)-(2S,5S,7R,8S)-1-aza-8-benzyloxycarbonyl-2,7-diphenyl-2-methyl-3-oxa-9-oxobicyclo[4.3.0]nonane 
• 591-51-5 phenyllithium 
• 736180-10-2 (-)-(2S,4R,5S)-2-hydroxymethyl-4-phenyl-5-benzyloxycarbonyl-6-piperidinone 
• 445474-60-2 (4R,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-4-phenyl-piperidin-2-one 
• 227930-65-6 (2S,4R)-6-Oxo-4-phenyl-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 227930-59-8 6-oxo-3,6-dihydro-2H-pyridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 

Downstream Products

• 445475-16-1 (4R,6S)-6-(4-Fluoro-phenoxymethyl)-4-phenyl-piperidin-2-one 
• 445475-37-6 (4R,6S)-4-Phenyl-6-phenylsulfanylmethyl-piperidin-2-one 

Relevant academic research and scientific papers

Enantiopure bicyclic piperidinones: Stereocontrolled conjugate additions leading to substituted piperidinones

The conjugate additions of Reformatsky reagents, organocuprate reagents, and hydroxylamines to a [4.3.0]-bicyclic enelactam derived from 6-oxopipecolic acid have been investigated, and found to be efficient, proceeding with excellent exo-stereocontrol, wi

Stereocontrolled synthesis of a prototype library of enantiopure 2,4-disubstituted 4-aryl-6-piperidinones and piperidines

Addition of a set of aryl cuprates to N-Boc O-TBDPS 2-hydroxymethyl 3,4-unsaturated 6-piperidinones affords syn-adducts in preference to anti when mixed Grignard-cuprates are used. Aryllithio cuprates give more of the anti-isomer in some cases. A library of 2-hydroxymethyl carbamates (27 compounds) and 2-hydroxymethyl aryl ethers and thioethers (19 compounds) was generated from a selection of 4-aryl-6-piperidinones, and some were further reduced to the corresponding piperidines (9 compounds).