445475-94-5

Basic information

• Product Name: 2-(4-methoxyphenyl)benzo[b]thiophene-3-carbonitrile
• Synonyms: 2-(4-methoxyphenyl)benzo[b]thiophene-3-carbonitrile
• CAS NO: 445475-94-5
• Molecular Weight: 265.335
• Mol File: 445475-94-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxyphenyl)benzo[b]thiophene-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)benzo[b]thiophene-3-carbonitrile(445475-94-5)
• EPA Substance Registry System: 2-(4-methoxyphenyl)benzo[b]thiophene-3-carbonitrile(445475-94-5)

Safety Data

• Hazardous Substances Data: 445475-94-5(Hazardous Substances Data)

Upstream product

• 2856-63-5 2-Chlorophenylacetonitrile 
• 5874-09-9 methyl (4-methoxyphenyl)carbodithioate 
• 326-62-5 2-fluorophenyl acetonitrile 
• 19472-74-3 2-(2-bromophenyl)acetonitrile 
• 40400-15-5 2-(2-iodophenyl)acetonitrile 
• 24434-84-2 benzo[b]thiophene-3-carbonitrile 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 696-62-8 para-iodoanisole 

Relevant articles and documents

Synthesis of Substituted Benzo[ b]thiophenes via Base-Promoted Domino Condensation-Intramolecular C-S Bond Formation

A novel synthesis of 2,3-substituted benzothiophenes is reported, involving a tandem base-mediated condensation of o-iodoarylacetonitriles/acetates/ketones with (hetero)aryldithioesters and an intramolecular C-S bond formation. The reaction affords divers

One-pot synthesis of 2,3-substituted benzo[b]thiophenes via Cu(i) catalysed intramolecular cyclisation from dithioesters

Efficient synthesis of benzo[b]thiophenes from o-halophenyl acetonitrile has been achieved. This novel one-pot procedure involves CuI and pivalic acid catalyzed C-S bond formation using dithioesters followed by a heterocyclization reaction. This efficient

Synthesis of new 2-arylbenzo[b]thiophenes using 'Heck-type' technology

Direct 3-substituted benzothiophene arylation using a Heck-type reaction with Pd(OAc)2/n-Bu4NBr as a catalytic system is reported. This reaction was found to perform relatively fast whatever the electron-donating or the electron-withdrawing group at position 3. We also extended this reaction to several aromatic halides, such as benzene, naphthalene and pyridine derivatives, synthesising new 2-arylbenzo[b]thiophenes in moderate to good yields.