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N-[2-chloro-5-(trifluoromethyl)phenyl]octanamide, also known as Icilin, is a synthetic amide compound that functions as a potent agonist of the transient receptor potential cation channel subfamily M member 8 (TRPM8). This channel plays a crucial role in the sensation of cold temperatures and the transmission of pain signals. Icilin has been extensively utilized in research to explore the physiological and pharmacological implications of TRPM8 activation, as well as its potential therapeutic applications in conditions like chronic pain and cold hypersensitivity.

4456-59-1

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4456-59-1 Usage

Uses

Used in Pharmaceutical Research:
N-[2-chloro-5-(trifluoromethyl)phenyl]octanamide is used as a research compound for investigating the role of TRPM8 in the sensation of cold and pain transmission. Its agonistic properties allow scientists to study the channel's function and the potential development of therapeutic agents targeting TRPM8 for conditions such as chronic pain and cold hypersensitivity.
Used in Cooling Agents:
In the cosmetics and personal care industry, N-[2-chloro-5-(trifluoromethyl)phenyl]octanamide is used as a cooling agent in topical creams and sprays. Its ability to activate TRPM8 channels can provide a cooling sensation when applied to the skin, making it a valuable ingredient in products designed to offer a refreshing and soothing effect.
Used in Drug Development:
N-[2-chloro-5-(trifluoromethyl)phenyl]octanamide is employed as a lead compound in the development of new drugs targeting TRPM8 channels. Its agonistic activity can be leveraged to create medications that alleviate chronic pain or manage cold hypersensitivity, offering potential therapeutic benefits for patients suffering from these conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 4456-59-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,4,5 and 6 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 4456-59:
(6*4)+(5*4)+(4*5)+(3*6)+(2*5)+(1*9)=101
101 % 10 = 1
So 4456-59-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H9ClN2O2/c1-8-11(6-7-17-8)13-15-12(16-18-13)9-2-4-10(14)5-3-9/h2-7H,1H3

4456-59-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[2-chloro-5-(trifluoromethyl)phenyl]octanamide

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:4456-59-1 SDS

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