4458-18-8 Usage
Uses
Used in Pharmaceutical Industry:
2,4-DIAMINO-5-AMINOMETHYL-PYRIMIDINE is used as a key intermediate in the synthesis of nucleotides for their essential role in DNA and RNA production.
Used in Antiviral Drug Production:
2,4-DIAMINO-5-AMINOMETHYL-PYRIMIDINE is used as a building block in the development of antiviral drugs, contributing to the creation of medications that combat viral infections.
Used in Anticancer Drug Production:
2,4-DIAMINO-5-AMINOMETHYL-PYRIMIDINE is utilized as a fundamental component in the production of anticancer drugs, aiding in the formulation of treatments that target and combat cancer cells.
Used as an Anti-inflammatory Agent:
2,4-DIAMINO-5-AMINOMETHYL-PYRIMIDINE has shown potential as an anti-inflammatory agent, making it a candidate for use in medications aimed at reducing inflammation and related symptoms.
Used in Organic Synthesis Reactions:
As a versatile chemical compound, 2,4-DIAMINO-5-AMINOMETHYL-PYRIMIDINE is also used as a building block for various organic synthesis reactions, further expanding its applications across different fields of chemistry and research.
Check Digit Verification of cas no
The CAS Registry Mumber 4458-18-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,4,5 and 8 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 4458-18:
(6*4)+(5*4)+(4*5)+(3*8)+(2*1)+(1*8)=98
98 % 10 = 8
So 4458-18-8 is a valid CAS Registry Number.
InChI:InChI=1/C5H9N5/c6-1-3-2-9-5(8)10-4(3)7/h2H,1,6H2,(H4,7,8,9,10)
4458-18-8Relevant articles and documents
Lewis acid-catalyzed synthesis of 4-aminopyrimidines: A scalable industrial process
Letinois, Ulla,Schuetz, Jan,Haerter, Ralph,Stoll, Rinke,Huffschmidt, Florian,Bonrath, Werner,Karge, Reinhard
supporting information, p. 427 - 431 (2013/05/09)
Pyrimidine synthesis starting from acrylonitrile has been known since the 1960s. The new Lewis acid-catalyzed condensation reaction allows the synthesis of 4-aminopyrimidines starting from the easily accessible chemical acrylonitrile without the need for carcinogenic chemicals and costly derivatization in up to 90% yield. The method is versatile and applicable for industrial-scale synthesis of biologically relevant substances such as vitamin B1 and trimethoprim.
Structure aided design of chimeric antibiotics
Karoli, Tomislav,Mamidyala, Sreeman K.,Zuegg, Johannes,Fry, Scott R.,Tee, Ernest H.L.,Bradford, Tanya A.,Madala, Praveen K.,Huang, Johnny X.,Ramu, Soumya,Butler, Mark S.,Cooper, Matthew A.
supporting information; experimental part, p. 2428 - 2433 (2012/05/19)
The rise of antibiotic resistance is of great clinical concern. One approach to reducing the development of resistance is to co-administer two or more antibiotics with different modes of action. However, it can be difficult to control the distribution and
