4458-65-5

Usage

Class

Pyrrole derivatives

Explanation

1H-Pyrrole-2,4-dicarboxylic acid, 5-formyl-3-methyl-, 4-ethyl 2-(phenylmethyl) ester is a chemical compound that belongs to the class of pyrrole derivatives.

Explanation

It is an esterified derivative of 5-formyl-3-methyl-1H-pyrrole-2,4-dicarboxylic acid with 4-ethyl-2-(phenylmethyl).

Explanation

The compound has potential biological and pharmacological activities, making it useful in the field of medicinal chemistry for the development of new drugs and pharmaceuticals.

Explanation

The molecular structure and properties of 1H-Pyrrole-2,4-dicarboxylic acid, 5-formyl-3-methyl-, 4-ethyl 2-(phenylmethyl) ester make it a versatile compound for various research and industrial applications.

Type

Esterified derivative

Potential activities

Biological and pharmacological

Molecular structure

Versatile

Upstream product

• 68999-91-7 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid 2-benzyl ester 4-ethyl ester 
• 123784-50-9 3-Methyl-5-nitrooxymethyl-1H-pyrrole-2,4-dicarboxylic acid 2-benzyl ester 4-ethyl ester 
• 5396-89-4 benzyl acetoacetate 
• 68999-77-9 5-chloromethyl-3-methyl-pyrrole-2,4-dicarboxylic acid 2-benzyl ester 4-ethyl ester 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 112452-43-4 benzyl 4-ethoxycarbonyl-5-(2-methoxycarbonylvinyl)-3-methylpyrrole-2-carboxylate 

Relevant academic research and scientific papers

REACTION ON SOLID SUPPORT PART V: THE MECHANISM OF OXIDATION OF α-METHYLPYRROLES TO α-FORMYLPYRROLES BY TALLIUM NITRATE ON CLAY

Evidence is presented to show that the clay-catalyzed thallium nitrate oxidation of α-methylpyrroles to α-formylpyrroles involves formation of an intermediate nitrate ester which subsequently undergoes elimination of nitrite.

Cyclizations of Terminally Substituted a,c-Biladiene Salts to give meso-Substituted Porphyrins

Cyclizations of 1',8'-disubstituted a,c-biladiene salts using copper(II) salts afford the corresponding meso-substituted porphyrins (after removal of copper) along with smaller amounts of the corresponding meso-unsubstituted analogues.For example, the a,c

Carbon-5 Regiospecific Synthesis of Deuteroporphyrin IX

Benzyl 3-(ethoxycarbonyl)-4-methyl-2-pyrrolecarboxylate was formylated with dimethylformamide (DMF)-phosphorous oxychloride, and the 5-formylpyrrole was obtained in 50percent yield.It was reduced with sodium borohydride to the alcohol, which was condensed with benzyl 3-methyl-4-(ethoxycarbonyl)-2-pyrrolecarboxylate to afford dibenzyldipyrrylmethane in good yield.The latter was transformed into its 5,5'-diformyl derivative which when condensed with bis-4-methylpyrryl>methane afforded the 3,8-bis(ethoxycarbonyl)deuteroporphyrin IX dimethyl ester in 40percent yield.Decarboxylation of the latter in hot hydrochloric acid gave deuteroporphyrin IX (isolated as its dimethyl ester) in 50percent yield.