4459-90-9

Usage

Chemical structure

Urea derivative with a 3-chlorophenyl group and a 2-hydroxyethyl group attached to the urea molecule

Industry use

Pharmaceutical industry as an intermediate for the synthesis of other organic compounds

Potential applications

Biomedical research and drug development due to its structural features and properties

Safety precautions

Handle with care and follow proper safety protocols to avoid health hazards

Physical state

Likely a solid at room temperature (based on molecular size and complexity)

Solubility

Likely soluble in polar solvents such as water or methanol (due to the presence of a hydroxyl group)

Stability

May be sensitive to heat, light, or moisture (common for organic compounds with functional groups)

Reactivity

Could potentially react with strong acids, bases, or nucleophiles (due to the presence of the urea and hydroxyl groups)

Storage

Should be stored in a cool, dry, and well-ventilated area, away from incompatible substances and in a sealed container to maintain stability and safety.

Upstream product

• 141-43-5 ethanolamine 
• 2909-38-8 m-chlorophenyl isocyanate 
• 91933-89-0 1-(m-chlorophenyl)-3-<2-(trimethylsiloxy)ethyl>urea 

Relevant academic research and scientific papers

IMPROVED INHIBITORS FOR THE SOLUBLE EPOXIDE HYDROLASE

Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases

Design, Synthesis, and Biological Activity of 1,3-Disubstituted Ureas as Potent Inhibitors of the Soluble Epoxide Hydrolase of Increased Water Solubility

The soluble epoxide hydrolase (sEH) is involved in the metabolism of endogenous chemical mediators that play an important role in blood pressure regulation and inflammation. 1,3-Disubstituted ureas are potent inhibitors of sEH that are active both in vitro and in vivo. However, their poor solubility in either water or lipid reduces their in vivo efficacy and makes them difficult to formulate. To improve these physical properties, the effect of incorporating polar functional groups into one of the alkyl chains was evaluated on their inhibitor potencies, water solubility, octanol/water partition coefficients (log P), and melting points. No loss of inhibition potency was observed when a polar functional group was incorporated at least five atoms (～7.5 ?) from the central urea carbonyl. In addition, the presence of a polar group at least 11 atoms away from the urea carbonyl group for the mouse and human sEHs, respectively, did not alter the inhibitor potency. The resulting compounds have better water solubility and generally lower log P values and melting points than nonfunctionalized liphophilic ureas. These properties will make the compounds more bioavailable and more soluble in either water- or oil-based formulations.