446-47-9

Basic information

• Product Name: 4,5-Diphenyl-1,3,2-dioxathiolane-2-oxide
• Synonyms: 4,5-Diphenyl-1,3,2-dioxathiolane-2-oxide
• CAS NO: 446-47-9
• Molecular Weight: 189.027
• Mol File: 446-47-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4,5-Diphenyl-1,3,2-dioxathiolane-2-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Diphenyl-1,3,2-dioxathiolane-2-oxide(446-47-9)
• EPA Substance Registry System: 4,5-Diphenyl-1,3,2-dioxathiolane-2-oxide(446-47-9)

Safety Data

• Hazardous Substances Data: 446-47-9(Hazardous Substances Data)

Upstream product

• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 95-46-5 2-methylphenyl bromide 
• 18982-54-2 o-bromobenzyl alcohol 

Downstream Products

• 1135540-89-4 1-(4-methoxyphenyl)-1-methyl-1,3-dihydroisobenzofuran 
• 89313-78-0 2-(p-tolyl)isoindoline-1-thione 
• 223924-91-2 4-(1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylbenzenamine 
• 93433-60-4 1-methyl-1-p-tolyl-1,3-dihydroisobenzofuran 
• 51293-53-9 1-methyl-1-phenyl-1,3-dihydroisobenzofuran 
• 1135540-79-2 1-(4-bromophenyl)-1,3-dihydroisobenzofuran 
• 128445-92-1 1-(2,6-Dimethoxyphenyl)-1,3-dihydroisobenzofuran 
• 4778-84-1 N-(4-methylphenyl)isoindolinone 
• 223924-74-1 1-(4-methoxyphenyl)-1,3-dihydroisobenzofuran 
• 7111-66-2 1-phenyl-1,3-dihydro-2-benzofuran 
• 1135540-95-2 1-(4-bromophenyl)-1-methyl-1,3-dihydroisobenzofuran 
• 1135540-93-0 1-(4-chlorophenyl)-1-methyl-1,3-dihydroisobenzofuran 
• 1135540-91-8 1-(4-fluorophenyl)-1-methyl-1,3-dihydroisobenzofuran 
• 85817-08-9 1-(4-fluorophenyl)-1,3-dihydroisobenzofuran 

Relevant articles and documents

SUBSTITUTED BENZOTHIOPHENE ANALOGS AS SELECTIVE ESTROGEN RECEPTOR DEGRADERS

In one aspect, the disclosure relates to relates to substituted benzothiophene analogs which are useful as selective degraders of estrogen receptor, methods of making same, pharmaceutical compositions comprising same, and methods of treating one or more clinical conditions associated with estrogen receptor, such as a cancer, including breast cancer, or osteoporosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Towards iron-catalysed suzuki biaryl cross-coupling: Unusual reactivity of 2-halobenzyl halides

The reaction of 2-halobenzyl halides with the borate anion Li[(Ph)(t-Bu)Bpin] leads not only to the expected arylation at the benzyl position, but also to some Suzuki biaryl cross-coupling. Preliminary mechanistic investigations hint towards the intermediacy of benzyl iron intermediates that can either: (a) directly cross-couple with the aryl boron reagent to give observed monoarylated species, or (b) undergo oxidative addition of the aryl halide to generate the diarylated species on reaction with the boron-based nucleophile.

Friedel-crafts reaction of benzyl fluorides: Selective activation of C-f bonds as enabled by hydrogen bonding

A Friedel-Crafts benzylation of arenes with benzyl fluorides has been developed. The reaction produces 1,1-diaryl alkanes in good yield under mild conditions without the need for a transition metal or a strong Lewis acid. A mechanism involving activation of the C-F bond through hydrogen bonding is proposed. This mode of activation enables the selective reaction of benzylic C-F bonds in the presence of other benzylic leaving groups.