446024-27-7Relevant academic research and scientific papers
An amino acid N-derivatising group that can be coloured on demand
Abell, Andrew D.,Martyn, Derek C.,May, Barnaby C.H.,Nabbs, Brent K.
, p. 3673 - 3675 (2002)
A method is presented whereby an amino acid is reacted with 5-formyl-1H-pyrrole-2-carboxylic acid to give an N-derivatised tag that has a latent ability to be coloured. A characteristic red pyrrolizin-3-one (coloured tag) is then revealed on treatment with hydrocinnamoyl chloride. This sequence has been carried out on amino acids in solution, and on solid phase, and also on dipeptides.
