446044-05-9

Upstream product

• 951-82-6 3,4,5-trimethoxyphenyl acetic acid 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 2196-99-8 2-chloro-1-(4-methoxyphenyl)ethanone 
• 182163-96-8 3,4,5-trimethoxyphenylboronic Acid 
• 441287-32-7 3-chloro-4-(4-methoxyphenyl)-2(5H)-furanone 

Downstream Products

• 1330677-07-0 5-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)benzylidene)-4-(4-bromophenyl)-3-(4-methoxyphenyl)furan-2(5H)-one 
• 910820-95-0 3-(4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-furan-2-carbaldehyde 

Relevant academic research and scientific papers

Photoswitching off the Antiproliferative Activity of Combretastatin A-4 Analogues

The photostability and antiproliferative activity of combretastatin A-4 (CA-4) analogues against human epidermoid carcinoma cells A-431 were studied. For the first time, it was shown that UV or sunlight irradiation of furanone analogues of CA-4 results in

Novel hybrids of fluconazole and furanones: Design, synthesis and antifungal activity

During our efforts to develop new antifungal agents, a number of hybrid molecules containing furanones and fluconazole pharmacophores were designed and synthesized. The new chemical entities thus synthesized were tested for their potential as antifungal a

Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents

We have synthesized rigid analogues of combretastatin bearing a furan ring in place of the olefinic bridge. These compounds are cytotoxic at nanomolar concentrations in neuroblastoma cells, display a similar structure-activity relationship compared to com

Mucochloric acid: A useful synthon for the selective synthesis of 4-aryl-3-chloro-2(5H)-furanones, (Z)-4-aryl-5-[1-(aryl)methylidenel-3-chloro-2(5H)-furanones and 3,4-diaryl-2(5H)-furanones

3,4-Dichloro-2(5H)-furanone, which has been prepared efficiently from mucochloric acid, has been transformed selectively into 4-aryl-3-chloro-2(5H)-furanones either by Suzukior Stille-type reactions. These monochloro derivatives have been used as precursors either to (Z)-4-aryl-5-[1-(aryl)methylidene]-3-chloro-2(5H)-furanones, including naturally occurring rubrolide M, or to unsymmetrical 3,4-diaryl-2(5H)-furanones. Some 2(5H)-furanone derivatives so prepared have been found to exhibit significant cytotoxic activity in vitro against the NCI three-cell-line panel, but limited cytotoxicity against the NCI human tumor 60 cell-line panel. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

Synthesis and cytotoxicity of 3,4-diaryl-2(5H)-furanones

A series of 3,4-diaryl-2(5H)-furanone derivatives were synthesized and evaluated for their cytotoxicity in a small panel of cancer cell lines. Four out of 10 compounds in this series, for example 3-(3,4,5-trimethoxyphenyl)-4-(4-methoxyphenyl)-, 3-(3,4,5-trimethoxyphenyl)-4-(3-hydroxy-4-methoxyphenyl)-, 3-(3,4,5-trimethoxyphenyl)-4-(3-amino-4-methoxyphenyl)-, and 3-(3,4,5-trimethoxyphenyl)-4-(2-naphthyl)-2(5H)-furanones, were found to have potent cytotoxic activities with ED50values of less than 20 nM in most of the cell lines tested.