446044-05-9Relevant articles and documents
Photoswitching off the Antiproliferative Activity of Combretastatin A-4 Analogues
Yadykov, Anton V.,Scherbakov, Alexander M.,Trofimova, Victoria V.,Lvov, Andrey G.,Markosyan, Ashot I.,Zavarzin, Igor V.,Shirinian, Valerii Z.
, p. 9608 - 9612 (2019)
The photostability and antiproliferative activity of combretastatin A-4 (CA-4) analogues against human epidermoid carcinoma cells A-431 were studied. For the first time, it was shown that UV or sunlight irradiation of furanone analogues of CA-4 results in
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents
Pirali, Tracey,Busacca, Sara,Beltrami, Lorena,Imovilli, Daniela,Pagliai, Francesca,Miglio, Gianluca,Massarotti, Alberto,Verotta, Luisella,Tron, Gian Cesare,Sorba, Giovanni,Genazzani, Armando A.
, p. 5372 - 5376 (2007/10/03)
We have synthesized rigid analogues of combretastatin bearing a furan ring in place of the olefinic bridge. These compounds are cytotoxic at nanomolar concentrations in neuroblastoma cells, display a similar structure-activity relationship compared to com
Synthesis and cytotoxicity of 3,4-diaryl-2(5H)-furanones
Kim, Yong,Nam, Nguyen-Hai,You, Young-Jae,Ahn, Byung-Zun
, p. 719 - 722 (2007/10/03)
A series of 3,4-diaryl-2(5H)-furanone derivatives were synthesized and evaluated for their cytotoxicity in a small panel of cancer cell lines. Four out of 10 compounds in this series, for example 3-(3,4,5-trimethoxyphenyl)-4-(4-methoxyphenyl)-, 3-(3,4,5-trimethoxyphenyl)-4-(3-hydroxy-4-methoxyphenyl)-, 3-(3,4,5-trimethoxyphenyl)-4-(3-amino-4-methoxyphenyl)-, and 3-(3,4,5-trimethoxyphenyl)-4-(2-naphthyl)-2(5H)-furanones, were found to have potent cytotoxic activities with ED50values of less than 20 nM in most of the cell lines tested.
