446286-90-4

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Bromo-5-(piperazin-1-yl)pyrazine is used as an intermediate in the synthesis of various pharmaceuticals for its potential pharmacological activity. It contributes to the development of new drugs that can address a range of medical conditions.
Used in Agrochemical Production:
In the agrochemical industry, 2-Bromo-5-(piperazin-1-yl)pyrazine is utilized as a key component in the production of various agrochemicals, enhancing crop protection and management strategies.
Used in Organic Synthesis:
2-Bromo-5-(piperazin-1-yl)pyrazine is employed as a building block in organic synthesis, allowing for the preparation of novel chemical compounds with potential applications in various fields, including materials science and specialty chemicals.

InChI:InChI=1/C8H11BrN4/c9-7-5-12-8(6-11-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2

Upstream product

• 34803-68-4 1-(pyrazin-2-yl)piperazine 
• 622386-08-7 5'-bromo-2,3,5,6-tetrahydro-1,2'-bipyrazinyl-4-carboxylic acid tert-butyl ester 
• 110-85-0 piperazine 
• 23229-26-7 2-5-dibromopyrazine 

Relevant academic research and scientific papers

INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE

Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

DIPIPERAZINYL KETONES AND RELATED ANALOGUES

Dipiperazinyl ketones and related analogues are provided, as are methods for their preparation and use. Such compounds may generally be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and therapeutic methods are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).

Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors

This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. Such hydroxamic acids generally correspond in structure to the following formula: (wherein A1, A2, Y, E1, E2, E3, and Rx are as defined in this specification), and further include salts of such compounds. This invention also is directed to compositions of such hydroxamic acids, intermediates for the syntheses of such hydroxamic acids, methods for making such hydroxamic acids, and methods for treating conditions (particularly pathological conditions) associated with MMP activity and/or aggrecanase activity.

Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives

This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.