4464-52-2Relevant academic research and scientific papers
Domino Synthesis of 2-Substituted Benzothiazoles by Base-Promoted Intramolecular C-S Bond Formation
Kumar, Yogendra,Ila, Hiriyakkanavar
supporting information, p. 7863 - 7867 (2019/10/11)
A new, transition-metal-free, domino synthesis of 2-substituted benzothiazoles has been developed, involving base-promoted one-pot addition of active methylene compounds to o-iodoarylisothioacyanates and subsequent intramolecular C-S bond formation of the
2-[1H-Benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides as kinase inhibitors
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Page/Page column 17, (2010/04/25)
2-[1H-benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and their salts are kinase inhibitors, useful in the treatment of cancer.
Synthesis of 4-amino-3-cyano-2-methylsulfanyl-1 H-[1,5]benzodiazepine, benzo[1,3]azole, and pyrazolobenzo[1,3]azole derivatives via a new utility of bis(methylsulfanyl)methylene derivatives
El-Rady, Eman A.,Khalil, Mohamed A.,Abd El Latif, Fawi M.
, p. 407 - 412 (2007/10/03)
Novel polysubstituted 1,5-benzodiazepine 5, 2,2-bis(methylthio)benzoxazoles 8a-d, 2,2-bis-(acetyl)benzoxazole 8e, 2-(3-methyl-1-phenylpyrazolo4-yl) benzoazole derivatives 16a-c, as well as the previously reported 2-di[cyano(acetyl)-methylene]benzothiazole
Chemical Interactions between 2-Mercaptobenzazoles and ?-Acceptors
Hassan, A. A.,Mohamed, N. K.,El-Tamany, E. H.,Ali, B. A.,Mourad, A. E.
, p. 653 - 662 (2007/10/02)
2-Mercaptobenzazoles (1a-c) interact with several ?-acceptors such as tetracyanoethylene (TCNE), 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), 2,3,5,6-tetrachloro-1,4-benzoquinone (CHL), dicyanomethyleneindane-1,3-dione (CNIND), 2,3-dicyano-1,4-naphthoquinone (DCNQ), 9-dicyanomethylene-2,4,7-trinitrofluorene (DTF), and 2,3-dichloro-1,4-naphthoquinone (DCHNQ) via the formation of charge-transfer (CT) complexes to yield various heterocyclic compounds. - Keywords: 2-Mercaptobenzazoles; Molecular interactions; ?-Acceptors
SYNTHESIS OF SOME NEW FUSED HETEROCYCLES CONTAINING A BRIDGEHEAD NITROGEN ATOM UNDER PTC CONDITIONS. A NEW APPLICATION OF CYANOKETENE S,S-ACETALS
El-Shafei, Ahmed Kamal,Soliman, Ahmed Mohamed,Sultan, Adel Abdel-Rahim,El-Saghier, Ahmed Mohamed Mohamed
, p. 115 - 118 (2007/10/02)
A novel synthesis of some fused heterocyclic compounds containing a bridgehead nitrogen atom was achieved using PTC conditions.Suitable ketene S,S-acetals were thus prepared and allowed to react with some o-substituted anilines to give (2,3-dihydrobenzothiazol-2-ylidenyl)malonodinitrile, 2a, ethyl (2,3-dihydrobenzothiazol-2-ylidenyl)cyanoacetate, 2b, (2,3-dihydrobenzoxazol-2-ylidenyl)malonodinitrile, 2c, ethyl (2,3-dihydrobenzoxazol-2-ylidenyl)cyanoacetate, 2d, (2,3-dihydrobenzimidazol-2-ylidenyl)malonodinitrile, 2e, and ethyl (2,3-dihydrobenzimidazol-2-ylidenyl)cyanoacetate, 2f.These afforded the desired products on reaction with a variety of halo compounds.
Synthesis, Reactions, and Tautomerism of Ketene N,S-Acetals with Benzothiazoline Ring
Huang, Zhi-Tang,Shi, Xian
, p. 541 - 547 (2007/10/02)
Ketene dithioacetals 2 react with 2-aminothiophenol to afford the corresponding substituted 2(3H)-methylenebenzothiazoles 3.Some compounds 3 react with α,β-unsaturated esters to give 1H-pyridobenzothiazole derivatives 4 and 5 by an electrophilic addition and cyclocondensation sequence.
