446823-67-2

Upstream product

• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 
• 446823-62-7 trans-(2S,5S)-bis(1-hydroxy-1,1-diphenylmethyl)pyrrolidine 
• 868-72-4 dimethyl 2,5-dibromohexanedioate 
• 868-72-4 dimethyl (2R,5S)-2,5-dibromohexanedioate 
• 446823-61-6 1-[(S)-1-phenylethyl]-trans-(2S,5S)-bis(1-hydroxy-1,1-diphenylmethyl)pyrrolidine 
• 134860-26-7 1-<(S)-1-Phenylethyl>-2,5-(S,S)-bis(methoxycarbonyl)pyrrolidine 

Relevant academic research and scientific papers

Synthesis of new, highly hindered C2-symmetric trans-(2S,5S)-disubstituted pyrrolidines

trans-(2S,5S)-(1,1-Diphenylmethyl)pyrrolidine has been prepared from the corresponding diester in four steps and 54% overall yield. Key steps involve the nucleophilic addition of an organomagnesiun reagent to a carbonyl compound promoted by cerium(III) ch