446839-07-2Relevant academic research and scientific papers
A greener, efficient approach to michael addition of barbituric acid to nitroalkene in aqueous diethylamine medium
Al-Najjar, Hany J.,Barakat, Assem,Al-Majid, Abdullah M.,Mabkhot, Yahia N.,Weber, Manuel,Ghabbour, Hazem A.,Fun, Hoong-Kun
, p. 1150 - 1162 (2014)
An efficient method for the synthesis of a variety of pyrimidine derivatives 3a-t by reaction of barbituric acids 1a,b as Michael donor with nitroalkenes 2a-k as Michael acceptor using an aqueous medium and diethylamine is described. This 1,4-Addition strategy offers several advantages, such as using an economic and environmentally benign reaction media, high yields, versatility, and shorter reaction times. The synthesized compounds were identified by 1H-NMR, 13C-NMR, CHN, IR, and MS. The structure of compound 3a was further confirmed by single crystal X-ray structure determination.
